Disintegration of tablets
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Theoretical materials on the website www.Tabletpress.ru
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Disintegration of tablets
Tablet must possess the necessary disintegration with sufficient mechanical strength. Too high tablet strength affects its disintegration and release of the drug substance - disintegration time increases, which adversely affects the quality of tablets. Disintegration depends a number of reasons:
1) on the amount of binding agents: tablets should contain an amount of binding agents which is necessary to achieve the required strength;
2) on the pressing pressure: excessive pressure worsens tablet disintegration;
3) on the quality of disintegrating substances promoting tablet disintegration;
4) on the properties of substances included in tablet, on their ability to dissolve in water, become moist, swell; tablets with readily soluble substances will decay faster and require fewer disintegrating agents.
The mass subjected to pressing, must have a set of properties, providing performance above requirements: dose accuracy, mechanical strength and disintegration.
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Tablet must possess the necessary disintegration with sufficient mechanical strength. Too high tablet strength affects its disintegration and release of the drug substance - disintegration time increases, which adversely affects the quality of tablets. Disintegration depends a number of reasons:
1) on the amount of binding agents: tablets should contain an amount of binding agents which is necessary to achieve the required strength;
2) on the pressing pressure: excessive pressure worsens tablet disintegration;
3) on the quality of disintegrating substances promoting tablet disintegration;
4) on the properties of substances included in tablet, on their ability to dissolve in water, become moist, swell; tablets with readily soluble substances will decay faster and require fewer disintegrating agents.
The mass subjected to pressing, must have a set of properties, providing performance above requirements: dose accuracy, mechanical strength and disintegration.
return...
return...
Questions about tablets
To all the questions related with production of tablets you can find answers on resource www.Tabletpress.ru
- How to mix powders correctly?Mixing of of powders, especially in unequal proportions, is very complicated process. It is impossible to identify the quality of mixing powder visually. When buying any powder mixer you should know some secrets of mixing powders from our website.
- How to granulate powders?Granules. Pharmaceutical granulation of powders, granules, as the final form of product or intermediate state of powder which improves flowability at pressing tablets. Learn more details from us.
- How to press powders?Many customers do not envisage the technology of powder pressing, for all that the powder should be uniform in composition, free-flowing well, with the minimum allowable humidity. Which factors influence positively, and which make it difficult to press tablets read on our site.
- How to cover a tablet?Pelleting of tablets - covering the tablet surface with protective and decorative coating. Select the shell material, study the technology of panning tablets and principles of Dragee pans.
- How to remove dust from tablets?In the process of compressing tablets at them, as well as on the working surfaces of the press formes a layer of powder. Further, when this layer of dust is not removed from tablets, it leads to malfunction of counting and filling machines, dusty tablet hinders coating solid shell. We share with you, what means to remove dust, dedust tablets.
- How to count and prepack tablets?After pressing, there is a question about packaging of tablets in container. Wherever necessary accurate counting of ready tablets, required precision counting machines for packing tablets. Read the review of such equipment.
- How to distinguish tablets from briquettes?Square tablets, oval tablets, circular tablets, tablets from salt, coal tablets, tablets with logotype, tablets for washing machines - which are tablets and which are briquettes already. Dimensions and shapes of tablets.
- How to pack tablets in blister?The most popular type of packaging of tablets - Blister contour cellular package. Blister packaging for tablets is PVC film and a layer of heat-sealing aluminum foil. Under high temperature are formed cells of desired shape, after filling, the top is sealed with aluminum foil.