About pressing of tablets

• The answer to the questionHow granulated powders obtaining a granule?Granules. Pharmaceutical granulation of powders, granules, as the final form of the product or an intermediate state improves the flowability of the powder when compressed tablets. Read more details with us.

1. Before looking granulator you must determine for themselves what task you are pursuing. If the pellets are the end product, and you want to pack them, you need to use one type of pellet. If you need the beads to give your powder uniformity and good fluidity, the granulator can choose cheaper and easier. Major differences in this case are in% of the mass of granules uniform. If your goal - getting ready pellets, you must obtain a one-dimensional granules with minimal presence of dust. If the granules need to apply powder in capsule or tablet press machine,% dust grains may be 20-40%. With such a high content of the tablet mass of powder, you can achieve the result - your loose powder will be enough.
2. Granulation there are 2 basic types - wet and dry. Wet granulation requires that the powder is moistened, the moisturizing liquid itself will be conducive to bonding agent. When moistened with water, to obtain pellets and let them dry, then after drying, there is no guarantee that the resulting granule is destroyed. The presence of an adhesive substance allow the pellet keep its shape. Granulation of powder humidification implies that the dry powder must be moistened to a certain extent, and then mixed with paddle mixers. This is required for a uniform distribution of moisture and adhesive substance throughout the mass of the powder. Wetted powder is rubbed through the holes perforated or woven mesh, where the shape of the pellets and gets (worm, cylinder or sphere). The granules obtained can not be used before dry completely. Can be used for drying ovens or furnaces. In the process of drying the granules may stick to each other, in the following, it is desirable to pass through a sieve shaker or simple.
3. Dry granulation. Main advantages - does not require the introduction into the gluing and other powder additives, does not require hydration and does not require subsequent drying. Cons - high costs and low productivity. Dry granulation process when moving between the two shafts at each other and having a longitudinal incisions fed dry powder. Getting between the shafts in cuts compacted powder in a small plate thickness. Powder, as would be compressed into a thin plate, which is removed from the surface of the shaft with knives. Further records are destroyed mechanically on the same fragments, usually square-shaped grains.
4. Before making a conscious choice in favor of a particular type of granulator is necessary to make the test board. Buy granulator is only possible after you get your mixed powder. Lacking powder and not knowing its properties selection granulator can give a bad result. Rely on the advice of a professional.

To all the questions related with production of tablets you can find answers on resource www.Tabletpress.ru