Preparation of powder for tabletting
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Theoretical materials on the website www.Tabletpress.ru
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Preparation of raw materials for manufacture of tablets.
Stages and the equipment used
Technology of production tablets for most chemical-pharmaceutical preparations
includes the following independent operations: weighing of raw material, its grinding, sieving, mixing, granulation, compression (tabletting), coating. At manufacture of pharmaceutical preparations, some of listed above operations can not be performed. Three basic and most common technological schemes of production tablets: direct compression, by using dry granulation, by using wet granulation.
Optimal selection the technological scheme for production of tablets is dependent on such factors as technological and physicochemical properties of drugs, the amount of drug in the tablet, drug resistance to adverse environmental conditions and others.
Technologist of pharmaceutical company chooses the technological parameters of tablet production according to the type of equipment used and the task.
In modern pharmaceutical industry is developing and improving analytical equipment that allows directly in the production process to analyze and control the set parameters of tablets.
Possible to see more detailed at every stage of tablet production the equipment used and stages of preparation of raw materials. At the manufacture of solid dosage forms, weighing is the initial phase and is carried out of the certain container for weighing the components in specific devices.
These devices provide
a) weighing of materials (solid, lamellar) according to their type or dose;
b) weighing of individual components or combinations of components directly in the production containers or in intermediate containers;
c) transfer of information about the results of weighing to centralized process control systems.
Stages and the equipment used
Technology of production tablets for most chemical-pharmaceutical preparations
includes the following independent operations: weighing of raw material, its grinding, sieving, mixing, granulation, compression (tabletting), coating. At manufacture of pharmaceutical preparations, some of listed above operations can not be performed. Three basic and most common technological schemes of production tablets: direct compression, by using dry granulation, by using wet granulation.
Optimal selection the technological scheme for production of tablets is dependent on such factors as technological and physicochemical properties of drugs, the amount of drug in the tablet, drug resistance to adverse environmental conditions and others.
Technologist of pharmaceutical company chooses the technological parameters of tablet production according to the type of equipment used and the task.
In modern pharmaceutical industry is developing and improving analytical equipment that allows directly in the production process to analyze and control the set parameters of tablets.
Possible to see more detailed at every stage of tablet production the equipment used and stages of preparation of raw materials. At the manufacture of solid dosage forms, weighing is the initial phase and is carried out of the certain container for weighing the components in specific devices.
These devices provide
a) weighing of materials (solid, lamellar) according to their type or dose;
b) weighing of individual components or combinations of components directly in the production containers or in intermediate containers;
c) transfer of information about the results of weighing to centralized process control systems.
Questions about tablets
To all the questions related with production of tablets you can find answers on resource www.Tabletpress.ru
- How to mix powders correctly?Mixing of of powders, especially in unequal proportions, is very complicated process. It is impossible to identify the quality of mixing powder visually. When buying any powder mixer you should know some secrets of mixing powders from our website.
- How to granulate powders?Granules. Pharmaceutical granulation of powders, granules, as the final form of product or intermediate state of powder which improves flowability at pressing tablets. Learn more details from us.
- How to press powders?Many customers do not envisage the technology of powder pressing, for all that the powder should be uniform in composition, free-flowing well, with the minimum allowable humidity. Which factors influence positively, and which make it difficult to press tablets read on our site.
- How to cover a tablet?Pelleting of tablets - covering the tablet surface with protective and decorative coating. Select the shell material, study the technology of panning tablets and principles of Dragee pans.
- How to remove dust from tablets?In the process of compressing tablets at them, as well as on the working surfaces of the press formes a layer of powder. Further, when this layer of dust is not removed from tablets, it leads to malfunction of counting and filling machines, dusty tablet hinders coating solid shell. We share with you, what means to remove dust, dedust tablets.
- How to count and prepack tablets?After pressing, there is a question about packaging of tablets in container. Wherever necessary accurate counting of ready tablets, required precision counting machines for packing tablets. Read the review of such equipment.
- How to distinguish tablets from briquettes?Square tablets, oval tablets, circular tablets, tablets from salt, coal tablets, tablets with logotype, tablets for washing machines - which are tablets and which are briquettes already. Dimensions and shapes of tablets.
- How to pack tablets in blister?The most popular type of packaging of tablets - Blister contour cellular package. Blister packaging for tablets is PVC film and a layer of heat-sealing aluminum foil. Under high temperature are formed cells of desired shape, after filling, the top is sealed with aluminum foil.